References

Maria Kleppe, Kaitlyn Shank, Papalexi Efthymia, Hugh Y. Rienhoff, Ross L. Levine “Lysine-Specific Histone Demethylase, LSD1, (KDM1A) As a Novel Therapeutic Target in Myeloproliferative Neoplasms” Blood Dec 2015, 126 (23) 601

William J. Harris, Xu Huang, James T. Lynch, Gary J. Spencer, James R. Hitchin, Yaoyong Li, Filippo Ciceri, Julian G. Blaser, Brigit F. Greystoke, Allan M. Jordan, Crispin J. Miller, Donald J. Ogilvie, Tim C.P. Somervaille, “The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells” Cancer Cell, Volume 21, Issue 4, 17 April 2012, pp 473-487 doi: http://dx.doi.org/10.1016/j.ccr.2012.03.014

Alyson A. Lokken, Nancy J. Zeleznik-Le “Breaking the LSD1/KDM1A Addiction: Therapeutic Targeting of the Epigenetic Modifier in AML” Cancer Cell, Volume 21, Issue 4, 17 April 2012, pp 451-453 http://dx.doi.org/10.1016/j.ccr.2012.03.027 Danielle Simmons, “Epigenetic Influences and Disease.” Nature Education 1(1):6, 2008 http://www.nature.com/scitable/topicpage/epigenetic-influences-and-disease-895#

Ronan T. Swords, Aymee Perez, Ana Rodriguez, Justin M. Watts, Fernando Vargas, Roy Elias, Hugh Y. Rienhoff, Arthur Zelent; The Small Molecule Img-98, a Potent and Selective Inhibitor of the Lysine Demethylase Lsd-1, Effectively Augments the Pro-Differentiation Effects of ATRA in a Pre-Clinical Model of AML. Blood 2015; 126 (23): 460.

Kristen Pettit, Aaron T. Gerds, Abdulraheem Yacoub, Justin M. Watts, Maciej Tartaczuch, Terrence J Bradley, Jake Shortt, William S. Stevenson, Natasha Joan Curtin, James M. Rossetti, Kate Burbury, Georges Natsoulis, Amber Jones, Moshe Talpaz, Jennifer Peppe, David M Ross, Hugh Young Rienhoff; A Phase 2a Study of the LSD1 Inhibitor Img-7289 (bomedemstat) for the Treatment of Myelofibrosis. Blood 2019; 134 (Supplement_1): 556. doi:

Sheng F Cai, S Haihua Chu, Aaron D Goldberg, Salma Parvin, Richard Koche, Jacob L Glass, Eytan M. Stein, Martin S. Tallman, Filiz Sen, Christopher Famulare, Monica Cusan, Chun-Hao Huang, Chun-Wei David Chen, Lihua Zou, Keith B Cordner, Vidushi Durani, Mitali Kini, Madison Rex, Johannes Zuber, Timour Baslan, Scott W. Lowe, Hugh Young Rienhoff, Ross L. Levine, Scott A. Armstrong; Leukemia Cell of Origin Influences p53 Activity and Therapeutic Sensitivity Via an Evi1-Dependent Mechanism. Blood 2019; 134 (Supplement_1): 109.

Jutzi JS, Kleppe M, Dias J, Staehle HF, Shank K, Teruya-Feldstein J, Gambheer SMM, Dierks C, Rienhoff HY Jr, Levine RL, Pahl HL. Hemasphere. 2018 Jun 8;2(3):e54. doi: 10.1097/HS9.0000000000000054. eCollection 2018 Jun.

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